The Angel and the Assassin:
The Tiny Brain Cell that Changed the Course of Medicine
(Random House/Ballantine 1/21/2020)
by Donna Jackson Nakazawa
A thrilling story of scientific detective work and medical potential that illuminates the newly understood role of microglia—an elusive type of brain cell that is vitally relevant to our everyday lives.
“The rarest of books: a combination of page-turning discovery and remarkably readable science journalism.”—Mark Hyman, MD, #1 New York Times bestselling author of Food: What the Heck Should I Eat?
NAMED ONE OF THE BEST BOOKS OF THE YEAR BY WIRED
Until recently, microglia were thought to be helpful but rather boring housekeeper brain cells. But a recent groundbreaking discovery has revealed that they connect our physical and mental health in surprising ways. When triggered—and anything that stirs up the immune system can activate microglia, including chronic stressors, trauma, and viral infections—they can contribute to memory problems, anxiety, depression, and Alzheimer’s. Under the right circumstances, however, microglia can be coaxed back into being angelic healers, able to repair the brain in ways that help alleviate symptoms and hold the promise to one day prevent disease.
A fascinating behind-the-scenes account of this cutting-edge science, The Angel and the Assassin also explores the implications of these game-changing discoveries for helping those who are suffering to find new pathways to healing. Award-winning journalist Donna Jackson Nakazawa illuminates this newly understood science, following practitioners and patients on the front lines of treatments, and witnesses patients finding significant relief from pressing symptoms, and at least one stunning recovery, offering new hope to the tens of millions who suffer from mental, cognitive, and physical health issues.
Hailed as “riveting,” “stunning,” and “visionary” The Angel and the Assassin offers us a radically reconceived picture of human health and promises to change everything we thought we knew about how to heal ourselves.
Praise for The Angel and the Assassin
“A fascinating deep dive into the unsung heroes (and villains) inside our skulls ….Donna Jackson Nakazawa has a journalist’s eye for story, a scholar’s understanding of the research, and patient’s appreciation for high the stakes truly are.”
—Susannah Cahalan, New York Times bestselling author of Brain on Fire
“An inspiring account…will provide a game-changing view of health for generations of researchers, clinicians and citizens for years to come. Bravo!”
—Dan Siegel, MD, Clinical Professor, UCLA School of Medicine, author of Mindsight
“The Angel and the Assassin is riveting, engaging. Nakazawa’s work is visionary.”
—Terry Wahls, MD, author The Wahls Protocol
“Few non-fiction writers can tell the tale of scientific inquiry so vividly the reader can feel the excitement of discovery with every word. Donna Jackson Nakazawa is one of those writers, and this book tells the tale of one of the most intriguing and groundbreaking discoveries in all of medicine.”
—Shannon Brownlee, Senior Vice President of the Lown Institute, author of Overtreated
“The Angel and the Assassin is one of those astonishing medical yarns that you almost can’t believe: how the power of this tiny cell was so long overlooked, how integral it has become to our understanding of neuroscience and immunology, the way it has transformed the most basic ideas of who we are as humans. It is especially essential reading for women, who face depression, Alzheimer’s and autoimmune disorders at higher rates than men.”
—Peggy Orenstein, New York Times bestselling author of Girls & Sex
“Colorful, page-turning, and accessible…. I have great hope for the practical application of what [Jackson Nakazawa] reveals.”
—Amy Myers, MD, New York Times bestselling author of The Autoimmune Solution
“Jackson Nakazawa puts forth a revolutionary new way of thinking about the brain’s immune system and its interactions with [the] rest of the body….Much of the information here was new to me, and has made me more optimistic about the future of medicine.”
—Andrew Weil, MD, New York Times bestselling author of Healthy Aging
“A deft, scientific story about the ‘Cinderella’ cell of the brain, microglia . . . Jackson Nakazawa explains the possible translation of the science into solutions for brain disorders, health and disease.”
—Thomas Insel, MD, Former Director, National Institute of Mental Health 2002 – 2015
“A captivating, page-turning story of the scientific discoveries that overturn centuries of medical dogma. The Angel and the Assassin offers extraordinary promise and heralds new hope … paradigm shifting reading for us all.”
—Christina Bethell, PhD, MBH, MPH, Professor of Child Health, Johns Hopkins Bloomberg School of Public Health
“An impressive, inspiring, timely call to arms.”
—Susannah Tye, PhD, Director of the Translational Neuroscience Laboratory, Mayo Clinic
“A captivating look at the new science altering our understanding of a range of conditions that especially affect women.”
—Maya Dusenbery, author of Doing Harm
“Provocative and eloquent of the cutting-edge research that proves the intimate connection between mind and body… Sets the stage for a paradigm shift for clinicians and researchers in the decades to come.”
—Ruth Lanius, MD, PhD, Professor of Psychiatry University of Western Ontario, coauthor of The Impact of Early Life Trauma on Health and Disease
“The Angel and the Assassin is a must read for everyone interested in the new science of brain health.”
—Louann Brizendine, MD, author of The Female Brain and The Male Brain