Countdown Reason # 3: Gratitude.

I’ve heard from so many of you who’ve reached out to share your well-wishes, as we get close to THE LAST BEST CURE hitting bookstores (both real and online) and becoming available for download. Just 36 hours to go!  I’m SO grateful for your enthusiasm and support. Just today, I’ve heard from a number of people who are setting up readings and book signings (stay tuned for details), from early reviewers, and from fellow authors, dear friends, and readers whose support means the world to me. Thank you. I feel such gratitude, and I happen to know, after a year of researching and test-driving how state of mind affects our neurobiology and physiology, that both extending well-wishes and feeling gratitude are healing for our brains, and for our cells. Thanks for reaching out — I can’t wait for the book to arrive in your hands. P.S. Don’t forget! February 21st is not only pubdate, it’s the day we announce the winners of the giveaway raffle — 5 books are going out to 5 people who’ve posted on my blog — so if you haven’t yet, post on my blog now for a chance to win a free book!

Countdown Reason # 4: “Look Who’s Reading Mom’s New Book!”

My daughter took this photo. I just had to share it, just for fun. When she showed it to my  husband, she said, smiling, “Dad, look who’s reading mom’s new book!” It made me smile. I can’t believe that on Thursday — in just 4 days — THE LAST BEST CURE will be available everywhere. Below, both of our dogs get in on the photo shoot!  

Countdown Reason #5: Look What’s Sitting On My Desk!!!!

                    Guess what just arrived at my house? My very own box of “author copies!” My daughter was so excited that she stacked them up on my desk and took this photo this afternoon. If you look carefully you’ll see a photo of my Dad behind the stacks of books — that photo always sits on my desk, where I write, right beside a photo of my children when they were young. My dad died from a complication from his chronic illnesses when I was growing up. He was also a journalist. So I guess I can’t help but think of how he might have smiled, if he’d had the chance to hold the books I write in his hands — or, even better, meet his grandchildren whose photos sit beside his. That’s why, I guess, I dedicated this book to him. This one’s for you, Dad!

Countdown Reason # 6: What Stress Does to the Gut, and What the Stressed Gut Does to the Brain

Two new studies tell us an interesting story about stress, the gut and the brain. We have a LOT of organisms in the gut. Cell for cell, we’re largely made up of bacteria. In fact, single-celled organisms, mostly bacteria, outnumber our own cells 10 to 1. Most of these live in our gut. Any alteration of the composition of good versus bad microorganisms in the gut —collectively known as our “microbiome”—impacts the state of our brain, making us more prone to anxiety, depression and low mood. And that lowered mood makes us more prone to feeling stressed out and reactive… which in turn further changes the composition of microorganisms in the gut… See the cycle? The first study appears in the journal Brain, Behavior, and Immunity. Researchers report that when we are under stress, the bacterial communities in our intestine become less diverse, allowing greater numbers of harmful bacteria to take over and party hearty. (We’ve pretty much known this for a while, after all, disorders of the gut such as irritable bowel and inflammatory bowel diseases are known to worsen during times of stress. But now we have the science to back up that clinical observation.) And that leads to the second study I wanted to talk about. It turns out that when bad bacteria are partying in our gut, it not only lowers our overall immunity, it lowers our overall mood. A sophisticated neural network transmits messages from those trillions of bacteria to our brain, exerting a powerful influence on our state of mind. That’s why scientists have begun to refer to our gut as “the second brain.” The idea that bacteria teeming in the gut can affect the mind “has just catapulted onto the scene,” say study authors. Our gut bacteria manufacture about 95 percent of our body’s supply of serotonin, which significantly influences our mood. In just the last few years evidence has piled up that the gut microbiome heavily influences our neural development, brain chemistry, emotional behavior, pain perception, learning, memory, and how our stress system is prepared to respond to life’s ups and downs. The more bad bacteria in our gut, the more anxious and moody and stressed out we feel. The more stressed out we feel the more we tip the microbial balance in the gut allowing more bad bacteria to thrive. Gastroenterologist Emeran Mayer, MD, director of the Center for Neurobiology of Stress at the University of California, Los Angeles, says that given the gut’s multifaceted ability to communicate with the brain “it’s almost unthinkable that the gut is not playing a critical role in mind states.” THE LAST BEST CURE is a toolbox to  intervene in that stress feedback cycle and help rescue both the brain in our gut and the brain in our head. — “Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation” by Michael T. Bailey, Scot E. Dowd, Jeffrey D. Galley, Amy R. Hufnagle, Rebecca G. Allen and Mark Lytee; and the brief commentary on it is “The gut microbiota: A new player in the innate immune stress response?” by Monika Fleshner. The article appears in Brain, Behavior, and Immunity, Volume 25, Number 3 (March 2011), published by Elsevier.

Countdown Reason # 7: Life Channel or Pain Channel?

Research tells us that although 70 % of our day is relatively good, 28 % of it neutral, and only about 2 % of what happens to us is actually bad, we think about that negative 2 % almost all the time; it’s what we ruminate over as we shower, drive, and fall asleep.[i] It reminds me of that old saying that we wear 2 % of our wardrobe 90 % of the time. We button ourselves up in our misery cloak a lot. I think of it this way. For most of us, two different sound tracks are playing simultaneously in our mind. I call them The Life Channel and The Pain Channel. It just depends which one we tune into — and turn up. The Life Channel is the channel on which uplifting and joyful moments play. It’s the feeling I get when I am braiding my daughter’s hair. Watching my family doubled over laughing at a bad joke at the dinner table. Holding hands with my husband, or my daughter (if she lets me) as we cross a parking lot. The feeling I get when I am staring at the snow covered trees as the sun transforms their icy branches into twinkling silver lights. Or when I am meditating, clearing the mind, focusing on nothing but my breath, and I manage (now and then) to reach that sweet spot of inner quiet, inner smiling. The aha of being half way through a yoga class, and realizing I’m in a peaceful place of well-being as I focus on every muscle and breath that goes into my downward facing dog. The joy of looking into one of my best friend’s eyes and feeling the inner love that’s exchanged in our haven’t-seen-you-in-far-too-long glance, in just an ordinary instant. The Pain Channel is where we live, however, most of the time. It blares our anger, resentment, fear. Our ruminations over what happened, how it shouldn’t have, what should be happening instead. Our self-doubt. Our regret and recrimination. Our physical pain and fear over any health issues we’re facing. Sometimes we have to be on The Pain Channel; it’s what wakes us up to deal with difficult situations, make change, take action. But we don’t need to be listening to The Pain Channel 90% of the time. We just don’t. We know The Pain Channel doesn’t feel good. We just don’t know how to shut it off. It’s powerful and seductive to get wrapped up in what’s playing on The Pain Channel, especially when we are feeling at our most vulnerable. We have to have the tools to reach out and turn The Pain Channel off — and turn The Life Channel on. THE LAST BEST CURE is about having a high-speed connection to dial up to The Life Channel, especially in those moments when we need it most. So we have a real chance at living life on the right track. [i] it’s what we ruminate over as we shower, drive, and fall asleep: Rick Hanson, Ph.D., and Richard Mendius, MD. Buddha’s Brain: the Practical Neuroscience of Happiness, Love and Wisdom. New Harbinger Publications, Oakland, CA, 2009.  To see a fascinating talk given by Hanson at Google in June 2010 see http://www.youtube.com/watch?v=0EM45CpeQb4.    

Countdown Reason # 8: How Did We Miss This Chronic Disease Epidemic?

How did we miss the chronic disease epidemic now facing America? And why are we so behind in meeting the needs of the 1 out of 2 adult Americans who suffer from them? I wanted to find out the answer to that question. So I reached out to Laurie Edwards, author of the upcoming book In the Kingdom of the Sick: A Social History of Chronic Illness in America (due out in April). Laurie teaches writing for the health sciences at Northeastern University. She blogs about chronic illness, health care, and writing at A Chronic Dose. I asked Laurie, “What has caused us to be so late out of the gate in meeting needs of patients with chronic illness, and in utilizing the new brain body science? Here is what Laurie had to say: “By and large, patients with chronic illness still navigate a medical system dominated by the biomedical model of disease, where patients are diagnosed, treated, and dismissed. This strategy is only effective with acute illness; after all, chronic conditions are treatable, but not curable. While many examples of a growing shift from this model exist—more centers with integrative care, or technology that allows patients and doctors to better collaborate in care, to name just a few—much work remains. Another reason we’re slower to meet the needs of those living with chronic illness is that we get hung up on a limited view of prevention – the idea of preventing illness. For many patients who face chronic conditions, prevention is more about slowing down disease progression. We need to be realistic about what the chronically ill population looks like. It is tempting to focus more exclusively on conditions like heart disease, diabetes, and lung disease when we think about chronic illness; after all, the seven most common chronic diseases are estimated to cost a staggering $1 trillion annually.  But this is an incomplete picture. Some 50 million Americans live with autoimmune disease, and a disproportionate number of these patients are women. An estimated twenty-five percent of the population lives with chronic pain and again, women suffer in higher numbers than men.  So many chronic conditions are “invisible illnesses”  – and this invisibility shrouds the physical realities that millions of people live with daily. The gender gap also plays an important role in why chronic disease has been underacknowledged. Research shows female patients’ reports of pain are taken less seriously, treated less aggressively, and they are more likely to be characterized as emotional or psychogenic. Sex-based research into pain is one step. Already, emerging research suggests differences in the ways men and women perceive pain. Chronic illness is incredibly complex, and these complexities feed into the delay in utilizing new brain-body science.  As you write in THE LAST BEST CURE, for so many patients, Western medicine has done all it can. Patients live with ongoing symptoms, try all sorts of lifestyle interventions and alternative therapies, and wonder if this is as good as it will get. While many recognize a fundamental mind-body connection, the idea that the brain itself could hold the key to healing is an enormous paradigm shift. Hopefully, science can give us more answers, and increased collaboration between patients and provides can help us put those answers into practice.” I thank Laurie for her response to my question. I think it’s spot on. We’re late to address the skyrocketing problem of chronic illness in America, for all the reasons she cites. We have much to do. I hope that THE LAST BEST CURE helps us to better understand the emerging scientific answers and to put those answers into practice.

Countdown Reason # 9: It Doesn’t Have to Be This Way

Today I was listening to NPR as I was driving. The discussion centered on new approaches to addiction — and the fact that addiction is now being classified as a “chronic brain disease.” Experts said that 22 million American’s suffer from it. (Add this to the 133 million Americans suffering from a range of other chronic diseases and the tally rises to 155 million Americans facing chronic health issues.) And guess what one of the successful new treatment strategies for this newly labeled “chronic brain disease” turns out to be? What do practitioners who treat patients with addiction feel is critical for patients if they hope to return to a state of well-being? “Manage their thoughts,” said both experts being interviewed. The phrase kept coming up: “Managing your thoughts plays a role in recovery.” Manage the negative Floating Brain.  Monkey Brain. The constant chatter of worry, the laser focus on what’s wrong with whatever is happening, or wishing for something else to be happening. Nursing anger, frustration, fear, anxiety, resentment, regret. Ruminating. Getting caught in those states of mind that are linked to setting forth a toxic cocktail of inflammatory hormones and chemicals from brain to body to cell. During the NPR show there was a pause for a commercial for an upcoming discussion about another rising health condition, the “disturbing rising rates of heart problems in young people.” We know that heart conditions are related to chronic and acute stress. Listening to this I thought we just have to find a way out of this American Stress Crisis and what it’s costing us. We just have to. In my year-long journey to find a way out, to find THE LAST BEST CURE, I test drove everything I thought might help the 155 million Americans who have chronic conditions. Everything that scientists know activates the healing responses of the brain. So that we can walk away from Monkey Brain, and live with a newfound sense of well-being. I also wanted to help the 145 million who don‘t face chronic health worries — and who don’t want to. I put every skill I possess as an investigative science journalist to use in the process. And when I listen to the radio for twenty minutes in the car and hear about the range of pain we face, whether from this emotional struggle or that health challenge, I find myself feeling, very deeply in my heart, how much I want to be part of the change. I hope THE LAST BEST CURE can help pave the way for change. Because it just doesn’t have to be this way.  

Countdown Reason # 10: Turtle Wushu, Anyone?

A week ago I wrote this at the end of a blog on joy, memories and the brain (see Countdown Reason # 19: Why Emotional Memories of Joy Matter so Much): “I’m going to think of how to make a joy memory today. I’ll let you know how that works out on an icy, windy Friday evening in a house with with two tired working parents at the end of the week and two teenagers.” I promised I would let you know how that went. Confession. It didn’t happen that Friday night. We unexpectedly had a house full of 14-year-old girls (who happen to be naturals at making joy happen). And then the week flew by in a blur of activities, work, events, homework, doctor’s appointments, and all that jazz. But this evening things were comparatively quiet and I asked my daughter if she’d help me get “the guys” (her dad and brother) to join us in a game of Turtle Wushu. We’d come across a video of it online and when we watched it we couldn’t stop laughing. Laughter is really great for our cells, and laughter is joyful. And a joyful state of mind activates what scientists call the “positive floating brain;” those juicy good chemicals that set out from the brain and travel through our organs and cells, helping to protect us from inflammation. Moreover, it protects us from the “negative floating brain,” that state of Monkey Mind — where our inner chatter raps on about what’s going wrong, what we have to get done, what we’re angry or frustrated about, the things we’re afraid of — causing our brain to send forth a constant slow drip of inflammatory hormones and chemicals. Okay, here is the video (short at 1:42) on how to play: Turtle Wushu. (We used small crackers instead of plastic turtles. It was even more fun because the dogs “played” too in hopes of getting the spoils.) If you have teenagers it can be hard to find a game that everyone wants to play, but we were “all in” at our house for Turtle Wushu. A half hour of chasing, turning, sly maneuvers around the kitchen island, sock sliding across the floor and whirling around the breakfast table, and we were laughing pretty hard. Later, I caught my son and husband playing “Wushu” in the kitchen, just the two of them, laughing. I got “Wushu-ed” a LOT (aka I kept losing!) so the dogs really stuck by my heels in hopes of getting those flying crackers. But I got something better — a silly and wild half hour with my family, away from homework, dishes, laundry, tomorrow’s to-do list, taxes (argh), and Monkey Brain. And that felt like winning.

Countdown Reason # 11: How This Journey Began

Sneak Preview! Here is the first half of the introduction to THE LAST BEST CURE, for those who had trouble reading the preview on my Penguin author page. It tells you about the place I found myself in when this journey began…. Introduction   This book began with my own sudden lockdown into the world of the chronically ill a little more than a decade ago. One day in 2001 I was pulling my daughter in a red wagon to the neighborhood pool to swim my evening mile in the lap lane. The next day I was paralyzed, unable to use my arms or legs, in Johns Hopkins Hospital with Guillain-Barre Syndrome, a disease similar to multiple sclerosis, but with more sudden onset and a wider array of possible outcomes. I slowly regained my ability to walk, drive, and tie my children’s shoes only to fall paralyzed with GBS again in 2005. The second recovery was harder, more tenuous. Although with miracle drugs and half a year of grueling physical therapy I could get down the steps and to my mailbox again, I still dealt with the neurological fallout of having had GBS twice — numb feet and hands, muscle spasms, poor reflexes and a flu-like lethargy that no amount of sleep could cure. Over the years other diagnoses unrelated to GBS had also thickened my chart: thyroiditis, more nerve damage, a clotting disorder, low red and white blood cell counts, bowel problems, slipped discs, and fevers of unknown origin. Every few months I’d end up back in crisis mode. My team of specialists – some of the best on the planet — pulled miracles out of thin air for me time and again. A pacemaker made my heart tick, and a small white pill kicked my thyroid into action each morning. Infusions of other peoples’ healthy immune fighter proteins, or antibodies — pooled from a thousand donors in a product known as immunoglobulin — replaced my faulty ones, and kept them from turning against me. The pattern was familiar: I would recover enough to drive, cook dinner, type stories on my computer again. And for that I felt lucky. But in the span of a decade I’d gone from being a healthy working mom who could swim 40 laps and stay up until two a.m. decorating a toddler’s birthday cake to being a revolving-door hospital patient – perpetually worried, exhausted, and often in pain. Above everything, I longed for a normal, ordinary life; to play hide and seek or jump in the ocean waves with my kids again, to go for a brisk morning swim with my husband. My team of specialists had pulled off miracle after miracle to keep me alive, but there was one cure they couldn’t offer me: they couldn’t give me back my capacity for joy. I felt robbed of joy. And there was no Rx for that. Something had been taken something from me, and I wanted it back. Meanwhile, the moments of everyday life that mattered most were spinning past. Life seemed to be increasing its speed while my own energy sputtered out. My best years with my children were almost behind me. My son was already in high school, my daughter nearly a teen. Soon, they would be gone. These were supposed to be my most productive and creative work years. And yet I was too tired and in too much pain to enjoy, keep up with it all, drink any of it in. I was stuck not only in my body, I felt stuck in place, held back from the full life I’d always thought I’d create for myself, for my family. It was starting to be too late to hope I’d ever have more than a half-life. A maybe life. This book was born out of that personal frustration. As a science journalist I did what I often do: searched for research trends that might give me insight as to how to solve the puzzle of my own life. For years, I’d been intrigued by the growing number of studies examining how our brain’s mental activity impacts our biology and well-being. But little of the science seemed geared to those facing chronic pain, discomfort or illness. Suddenly, however, the research had taken a quantum leap. Neurobiologists at the best research institutes in the world were finding myriad ways to peer inside the body and demonstrate how specific practices could activate robust healing responses in the brain, making us not only feel better, but creating lasting biological changes in our physical bodies and cells. One new area of mind-body medicine intrigued me in particular: the relatively new and burgeoning field called psychoneuroimmunology, or PNI. Psychoneuroimmunology is the study of the potent interaction between our psychological state of mind and our cellular and immune function. It examines the direct influence that states of mind — ranging from contentedness and well-being to joy and delight — have on the messages our brain sends to our immune system, our nerves, and our cells. In simplest terms, the science of PNI – or what I have heard a few scientists call for simplicity’s sake, PIN, or psycho-immu-neurology – is the study of how our mental and emotional state, the very way we think and act, can maximize our ability to heal — and enhance our overall physical health. Their findings were giving new credence to the idea that the mind-body connection plays a critical and even determining role in our physical condition. Moreover, research was beginning to focus specifically on helping patients with chronic conditions to relieve emotional and physical pain and suffering. Emerging data was showing that those with chronic conditions who practiced specific mind body approaches were able to move their emotional state away from anxiety and pain — and toward more joy and well being. In the process, their levels of inflammatory biomarkers and stress hormones – those linked to a range of diseases including fibromyalgia, digestive illnesses, Alzheimer’s, autoimmune disease,

Countdown Reason # 12: The Number of Kids with Chronic Conditions is Skyrocketing

I’ve written about how chronic pain is on the rise, as are rates of chronic disorders. But two new studies extend our knowledge about the prevalence of chronic conditions among Americans into an area that’s quite troubling: America’s children. One study, published in the journal PAIN found that “recurrent chronic pain is overwhelmingly prevalent in children and adolescents, with, 11% to 38% of kids reporting pain.” Study authors looked at headache, back pain, abdominal pain, muscle pain and generalized pain. Rates depended on the sort of pain being reported. For instance one in four youth reported having regular headaches. Girls generally experience more pain than boys. Which is not surprising since women suffer from more chronic conditions than men in adulthood. What is most concerning, say investigators, is this: “… prevalence rates of childhood pain have increased over the last several decades.” Stress is most certainly playing a role. The second study, published in the journal Archives of Pediatric and Adolescent Medicine found that children and teen’s chronic pain is associated with that of their parents. The more chronic pain parents experienced — especially mothers — the more their children reported chronic pain: “…clear associations were observed between maternal pain and pain in adolescents and young adults…” As adults, we need to look at managing our own sense of joy and well-being not just in terms of our own health, but that of our children. Every step we take to move past “stressed-out living” and reclaim joy in our life not only enriches us, it allows our kids to see how that’s possible. And that legacy is priceless. —– Sara King, Christine T. Chambers, Anna Huguet, Rebecca C. MacNevin, Patrick J. McGrath, Louise Parker, Amanda J. MacDonald. The epidemiology of chronic pain in children and adolescents revisited: A systematic review. PAIN, 2011; 152 (12): 2729 DOI: 10.1016/j.pain.2011.07.016 (Arch Pediatr Adolesc Med. Published online November 19, 2012. doi:10.1001/jamapediatrics.2013.428.